In modern economic terms, healthy population is seen as an impol'lant engine of economicrngrowth. Despite technological advancement in both prevention and treatment practice in thern2 (" centwy, malaria is still a major cause of morbidity and mortality in the past threerndecade. Malaria is not only a health problem but also a developmental problem. It placesrnsignificant financial hardships on both households and the economy Malaria is a longrnstanding major health problem in Kedida Gamela Woreda of Kembata Tembaro zone, whichrnis located in the central region of SNNPR, Ethiopia. So the paperfocuses to investigate thernfactors that affect the knowledge, allitude and practice of the woreda community towardsrnpreventing malaria. The study was a survey type, both primm)' and secondmy data vererncollected Primmy data was obtained through structured questionnaire, key infal'lnanlrninterview and focus group discussion Secondmy data was obtained ji-om published andrnunpublished materi"ls, project reports and maps, A total of 422 sample respondents werernidentified using cluster random sampling technique. The study was conducted ji-om March jrnlip to March 17, 2009. The analysis was made at an individual level using bi-variate andrnIIIl1lti-variate methods. By which this helps to identifY the socia-economic, demographicrnstalUs of the household and cOl1lmunity in that specific locality The result of bi-variaternanalysis showed that the demogmphic and socia-economic factors had relationship withrnrespondents ' knowledge, allitude and practice. Moreover, significant proportion of thernrespondents had knowledge, positive allitude but poor practices of malaria prevention Thisrnsituation had been observed across all the demographic and socio-economic characteristicsrnolthe respondents. The chi sqllare and cross tab correlation analysis also slnlll'ed tlwtrnaccess to any form of medias, level of income, participation on environlllental S{{/lltwyrnlIIanagement, contact with health extension workers, literacy status, and occupation ",cr"rnfound /() be significantly related to knowledge and allitude. Nevertheless, sex, marital,l'tatlls,rnage, place of residence and household size were not statistically associated with knowledgernand allitude. Based on the .findings, the following points of recommendations were stat eli:rnproviding health education, improving the environmental dimension, searching alternativernsources of trans milling health education and continuing the work done by NGOs