Context: To initiate meaningful prcv ~ nti vc measureS ror the prevent ion ane! COl1trol ofrnIII V/IIJ)S. there is a need to have inCormation on the perception and knowlcdgc ofrnstudents and the scxual l1L:havior uf st udent s which form a signifi ca nt at risk group.rnOhjectives: The ultimate ohject ive or this study is to investiga te till' factors whi chrnaggravate the vuln erability or st uden ts to III V/IIJ)S .rnMethods: A cross sect ional survey is condu cted on thc knowledge and percept ion.rnvulncrab ility and sex ual behavior of studellis among 4 16 students that were se lcctedrnusing rnu lti -stagc stratiried simple random sa mpling tech niq ue. Six rocus grouprndiscuss ions each con taining eight members were conducted . In this cii sc li ssion 18 femalernand 30 nlaic studcnts participatcd. Descripti ve and some in fe rential statisti cs like Chisquarerntest: binary logistic and muitinoill ial regreSSIon were used to assess thernvulnerab ility of stuci ents to III V/A IDS.rnl~t'slll1s : lllost students have knowledge on the rouies or transmiss ion and prevent ion ofrnIII V/II I)S. More than