The General objective was to analyze the direct and indirect major determinantsrnaffecting the prevalence of HIV in Amhara region across the selected urban andrnrural areas. Based on Dixon and Leach's [1978] formula, a total of 493 subjectsrnwho are eligible were selected and included in the populations for the householdrnsurvey. Moreover, Logistics regression models were fitted based on results foundrnto be significant in Chi Square and bivariate an