The Assessment of the Effects of Water Sanitation on Human Health and Livelihoods wasrnconducted in Kechene and Shiromeda areas, Gullele Sub-city, Addis Ababa, Ethi opia. Thernassessment was an important problem assessed. The problem was limited access to water,rnpoor sanitation (defecation, urination, and efflue nts) and hygiene (personal and house cleanliness)rnthat affected water quality or hygiene affected because of limited access. The assessmentrnwas to conduct a survey of Knowledge, Attitude and Practice of the households on waterrnsupply, storage, sanitation, hygiene, quality and treatment. Assess bacteriological andrnphysico- chemical pollution of water on human health. Assess the effect of water access andrnpoll ution on income and li vel ihoods. Conclude and recommend possible strategies to curbrnthe problems. The methodology employed was household Knowledge, Attitude and Practicern(KAP) survey and laboratory test of water. The survey employed 155 questionnaire administrationrnand schedule, 6 key informant interviews and 3 focus group discussions. The laboratoryrnincluded water sample collection for Physico chemical and bacteriological test. The surveyrnresu lt showed that limited access to water created competing water demands and needsrnfor household activities. It affected water consumption, use and norms. Laboratory test conductedrnhad shown that household connections and sto rage containers had substances likernIron, Manganese, Chl oride, PH, Total Dissolved Solids (TDS), Electrolyte Conductivity (Ec)rnand turb idity. The presence of total coliforms, E.coli and ammonia was detected in drinki ngrnwater. The assessment confirmed that water access, sanitation and hygiene have affected thernhealth, income and li ve lihoods of the people in the study areas.rnKeywords: Human Health, Livelihoods, Bacteriological , Phys ico chemical and Survey