The objective of this study was to assess the socia-economic burden o( malaria in Zeghiernpeninsula. To do this, a combination of quantitative and qualitative research techniquesrnwas ernployed at two kebeles in the peninsula. One hundred and .fifty three householdrnheads of both sexes were interviewed. Data collection tools, like surveying, .focus grouprndiscussion, key in(ormant interview and .filed observations were used in carrying out thisrnstudy. As common problems in developing countries, various types of in(ectious diseasesrnwere most Fequently diagnosed in the clinic in the peninsula. O( all other healthrnproblems malaria wasfound to be the most important parasitic disease in the selling andrnnearby rural farming communities. The major socia-economic impaci of malaria isrnresponsible for the reduction of the labour force o(families, obstructing education.rndisruption (j( cultural values (indirect costs), and worsening o( health condition 0/ therncommunity (direct cost). It was found that the indirect cost (j( malaria illness accountedrnas a loss (j(mean average 365.28 Birr, which is 22.46% o/the mean annual income (j/ arnhousehold. Besides, the direct cost accounted a mean average o( /30.11 Birr (8.68%) (jfrnthe household 's annual income. The aftermath of malaria illness was also envisaged inrnthe study area as low birth weight, still birth, induced abortion, and maternity deathsrnrelated to pregnancy. Even afier recovery Fom malaria, the study community encountersrnanemia, visual and hearing impairments, under nourishment (due to loss (j( appetite), andrngastric. problem. The disease has also a negative impact on education per(ormance o(rnstucients sllch as school absenteeism and dropout. Under treated malaria patients in thernpeninsula were forced to disregard their cultural as well as religious values in abslainingrnfasting seasons and changed their feeding habit. Due to the relatively beller literacy raternand level (j( education among the community, the awareness about malaria has seeminglyrnimproved. However, fill'ther effort has remained so as to decrease the socia-economicrnimpacts o( malaria on the community. In turn, this could be the other side a/taking arnpalliative measure to alleviate poverty in the selling as well as in the country at large.