IntroductionrnThyroid diseases are common endocrine disorders with a number of potentially serious rncomplications. There are inadequate recent studies addressing the clinical picture of thyroidrndiseases in Ethiopia. rnObjectives rnThe aim of this study was to assess the pattern and clinical presentations thyroid disorders. rnMethodsrnA cross-sectional study was conducted on successive thyroid disease patients visitingrnEndocrinology Referral Clinic of TASH from Feb 2020 to June 2020 were included in thisrnstudy. A retrospective medical chart review was carried out. Certain socio-demographicrnparameters and clinical characteristics of patients were assessed. Descriptive analysis was usedrnfor statistical analysis. The data was processed, summarized and presented in the form ofrnnarratives & tables. rnResults rnA total of 271 patients, 86.3% female and 13.7% male, with an age range of 14 to 81 yearsrnwere included. And 60.5% of the patients were 40 to 81 years. Among all, 56.8% had overtrnhyperthyroidism and 39.5% had hypothyroidism while subclinical hypothyroidism andrnsubclinical hyperthyroidism were documented in 2.6% & 1.1% of the patients. TMNG wasrnresponsible for 55.8% of hyperthyroidism cases as primary hypothyroidism accounted forrn53.3% of the hypothyroidism cases. Palpitation (54.7%), goitre (26.4%), heat intolerancern(25.9%) & hyperhidrosis (10.7%) were the commonest presentations of thyrotoxicosis,rnwhereas hypothyroidism patients presented mostly with fatigue (49.1%), menstrual disturbancern(25%), cold intolerance (20.5%) & weight gain (14.3%). rnConclusionrnThyroid diseases were more common in females and more prevalent in old age. More than halfrnof the thyroid disorders were caused by TMNG and primary hypothyroidism. The mostrncommon presenting feature of thyrotoxicosis was palpitation, and of hypothyroidism, fatigue.rnTherefore, it is better to reinforce multidisciplinary approach, and introduce radioactive iodinernuptake study and radioactive iodine therapy.