Background rnDiabetes is a growing public health challenge worldwide, including Ethiopia. Comprehensivernmultifactorial cardiovascular risk reduction is recommended to reduce diabetes-associated rnmorbidity and mortality but achieving the triplet goals (optimization of blood glucose, bloodrnpressure and low density lipoprotein levels) remained a global clinical challenge. Patientsâ€™rnknowledge of these therapeutic goals of diabetes care contributes to improved self-care and rnglycemic control. However, the patientsâ€™ knowledge of the therapeutic goals in diabetes and itsrndeterminants have not been studied comprehensively in Ethiopia. rnObjective rnThis study was conducted to assess patientsâ€™ knowledge of the therapeutic goals of diabetesrnmanagement and the factors associated with the knowledge score. rnMethods rnA cross-sectional survey was conducted from March 3 to June 10, 2020, at the diabetes clinic inrnTikur Anbessa Specialized Hospital. Data were collected using a pretested, structured, intervieweradministeredrnrnquestionnaire. Then, the open data kit (ODK) completed form was exported andrnanalyzed using SPSS version 25. To identify determinants of knowledge, bivariable and rnmultivariable binary logistic regression analyses were done. Statistical significance wasrnconsidered at the level of significance of 5%, and adjusted odds ratio (AOR) with 95% confidence rninterval (CI) was used to present the estimates of the strength of the association rnResults rnA total of 419 participants were included. The mean knowledge score was 4.7 Â±2.2 points (out ofrn10). Overall, the percentage of patients with a good understanding of the therapeutic goals ofrndiabetes management was 59.5%. The percentages of patients who reported knowing their target rngoals for blood pressure, fasting blood sugar, hemoglobin A1C, and low-density lipoprotein werern79.5, 77.3, 11.7, and 7.2% respectively. Correct target goals for BP, FBS, A1c, and LDL-C werernreported by 75.7, 73.0, 4.1, and 1.0% respectively. The percentages of patients who reported knowing their recent levels for BP, FBS, A1C, and LDL-C were 72.3, 80.2, 16.7, and 8.1%rnrespectively. The multivariable binary regression analysis demonstrated that patients with longer rndiabetes duration (AOR = 1.04, 95% CI: 1.01-1.07) and an increased household income by 1000rnEthiopian birr (AOR = 1.12, 95% CI: 1.02-1.23) were associated with the odds of having good rnknowledge of the therapeutic goals. For each one year increase in the age of participants, the oddsrnof having good knowledge of diabetes therapeutic goals decreases by 3% [AOR = 0.97; 95% CI:rn0.95-0.99]. However, compared to higher education level, having no formal education or primary rneducation was significantly associated with poor knowledge (AOR = 0.03; 95% CI: 0.006-0.13rnand AOR = 0.27; 95% CI: 0.15-0.49, respectively). Besides, the odds of having good knowledge rnof the therapeutic goals for divorced patients with diabetes decreases by 63% as compared tornmarried participants [AOR = 0.37%; 95% CI: 0.18-0.76]. rnConclusion: This study demonstrated that the majority of participants knew their BP and FBSrntargets and own recent levels while only a minority of patients understood their A1c and LDL-Crntargets and recent values. It highlighted the need for the provision of patient-centered diabetic rneducation and sharing responsibility for patients achieving diabetes treatment goals.