Clinical And Imaging Characterization Of Patients With Focal Liver Lesions With Emphasis On Hepatocellullar Carcinoma At Tikur Anbessa Specialized Hospital (tash) From August1 2019to July30 2020.

AbstractrnBackground: The accurate and reliable determination of the nature of the liver mass is rncritical, not only to reassure individuals with benign lesions but also, and perhaps morernimportantly, to ensure that malignant lesions are diagnosed correctly. Accurate diagnosis allowsrnthe appropriate selection of optimal management. rnObjective: This study was aimed to assess clinical and imaging characterization in patientsrnwith focal liver lesions with emphasis on HCC at Tikur Anbessa specialized hospital (TASH) rnfrom august1, 2019 to july30, 2020. rnMethod: Institution based descriptive and retrospective study was conducted from August 1,rn2019 to July 30, 2020. A total of 135 patients with imaging result of focal liver lesion were rnincluded in the study data was collected using standardized questionnaire. Clinical and imagingrnpattern was assessed from records. Summary statistics like mean and median were computed.rnBoth bivariate and multivariate logistic regression was fitted to identify associated variables. Arn95% confidence interval odds ratio (OR) was computed and considered variables having p -rnvalue less than 0.05 in the multi variable model as significantly associated with the dependentrnvariables. rnResult: A total of 135 patients were included in the study. The mean age was 49.83(SD 13.866)rnyears. Most of the patients were from Addis Ababa and Oromia (82.3%). Majority of lesions in rnthis study were malignant (81%), hepatocellular carcinoma (63%) and hemangioma (29.9%)rnbeing the commonest malignant and benign lesions respectively. Many of the lesions werernsolitary (62%) and size ≥5cm. right lobe was mostly involved (57.1%). Abdominal pain was therncommonest presentation (74.8%) in most of the patient. HBV (22.2%) and HCV(7.4%) infectionrnwas significantly associated with hepatocellular carcinoma among the risk factors. rnrnConclusion: Majority of lesions in this study were malignant and solitary. Hepatocellular rncarcinoma and hemangioma were commonest malignant and benign lesions respectively. Right rnlobe was mostly involved and abdominal pain was the commonest presentation in most of thernpatient. Among the risk factors HBV and HCV infection was significantly associated withrnhepatocellular carcinoma. rn rnGrant source: Addis Ababa University, college of health sciences, school of medicine

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