The development of modern biotechnology raise environmental and health relatedrnrisks. In protecting both the environment and human health states came up withrninternational and national biosafety framework. This study has made arncomprehensive assessment on biosafety framework of Ethiopia and its sufficiency inrnimplementing the CPB. The study aimed at assessing whether proper procedures arernfollowed in the approval of Bt Cotton and GM Maize and whether the publicrnawareness, participation, BCH, and risk assessment issues are addressed under therndomestic law and being implemented in Ethiopia, among others. The researcherrnbeyond consulting laws and other secondary sources conducted an interview with keyrninformants from different regulatory agencies. Although the Ethiopian biosafetyrnframework is in line with the CPB, it doesnâ€™t sufficiently assure properrnimplementation of the latter. The study has identified legal and implementation gapsrnconcerning biosafety i.e. limited public awareness and participation, weak borderrncontrol attributed to lack of skilled man power and laboratories, and weakrncollaboration between the EFCCC and the ECC, and failure to address liability andrnredress issues due to governmentâ€™s reluctance to adopt a sui generis law. Concerningrnthe practice there were flows in the implementation of AIA, public participation, riskrnassessment, and BCH in the approval procedures of Bt Cotton and GM maize. Basedon its findings, the study recommends straightening the biosafety legal andrninstitutional framework and implementing the CPB and domestic laws properly in the