Trachoma is the world's leading cause of infectious blindness. It is an infectious disease of the eyerncaused by the bacterium Chlamydia trachomatis. Elimination of blinding trachoma through thernsurgery, drug administration, facial cleanness and environmental sanitation are strategyrnStrategies. MDA of all affected to eliminate trachoma depend on people in endemic areas receivingrnthe medicines or drugs they need in the places where they live, at appropriate regular intervalsrnand this contribute paramount importance in blinding trachoma elimination. This requiresrnefficient trachoma medicines supply chain management. Woreda health offices are crucialrnadministrative bodies in strengthening and implementing trachoma medicines supply chainrnmanagement. Therefore, it is aimed assess the supply chain management of medicines used forrntrachoma mass drug administration in Woreda health offices of North Shewa zone in Amhararnregion. A descriptive approach was employed to asses of supply chain management of medicinesrnused in mass treatment of trachoma in Woreda health offices of North Shewa Zone, Amhara region,rnEthiopiaâ€. Survey method was used to collect data. In addition, interview guides and observationsrnwere some of the tools used in the data collection process. In is found in most Woredas that therernis only one logistics officer to manage Woredas store and supply management. The result indicatesrnthat most supply chain management components are not being properly managed except forrnkeeping reporting timelines. Storage management is the most affected supply component which isrnprobably due to workload and storage space problem. In conclusion, Supply chain managementrnof trachoma medicines at most is not being managed as per the national and internationalrnstandards which needs further studies to find out a key problem and zonal health departmentrnpharmaceuticals department have to provide continue supports and the stakeholders have tornstrongly support Woreda logistics officers to strengthen the supply chain to create efficient supplyrnsystem.