The objectives of this research areto assess the spend in the total expenditure, and supply riskrn(supplier availability rate) of regular medicines; to identify the category or position of eachrnregular medicine according to: Leverage, Critical (strategic), Routine (non-critical), or Bottlernneck items quadrant; and to assess tender processing periodat Ethiopian PharmaceuticalsrnSupply Agency (EPSA). The study used descriptive research design with quantitative researchrnapproach and documentary analysis of pure secondary data. The position of each regularrnmedicine has been quantified empirically using secondary data from three years procurementrnrecord of the agency. Based on rigorous analysis of these data, 7.65% and 0.76% of the totalrnitems procured within these years have been found to fall in leverage and strategic itemrnquadrant while 60.09% and 31.5% fell in non-critical and bottle neck quadrant of the matrixrnrespectively. The finding on item category analysis indicates a profound problem of deviationrnfrom the typical item positioning feature which occurred because of the presence of leastrnprocured items and lack of suppliers for some number of items. The limitation of this study isrnthat only the total FOB price and supplier availability rate of pharmaceuticals were taken asrnthe basic variables to categorize items on the vertical and horizontal axes of Kraljic portfoliornmodel.