The purpose of this study is to assess Total Quality Management (TQM) practices inrnEthiopian pharmaceuticals S.C. TQM is a factor of its principles and practices namelyrncustomer focus, Leadership, Engagement of People, Process Approach, Evidence basedrndecision making and Supplier relationship. Hence, the research tried to assess whether thesernprinciples are practiced in the organization.The research tried to obtain both primary andrnsecondary data. The primary data was obtained from employees of Epharm using semistructuredrnquestionnaire and Interview questions The secondary sources of data were thernliteratures available and the documents related to TQM that are kept by the organization.Therndata collected was analyzed and presented with tables and percentages using SPSS.rnFurthermore to estimate error or how well the sample represented the population, confidencerninterval method was employedThe general population of the research is all 220 employees ofrnEpharm. These 220 employees are of different departments, experience and exposure tornquality related issues.33 out of these 220 employees are managers and supervisors thus 187rnemployees are non-managers.Since quality is a factor of all the parties in an organization, allrn220 employees from all departments have chance to be included in the sample.rnHowever,different sampling techniques employed for each department. The results of thisrnpaper shows that majority of the employees agree that Epharm is practicing all the sevenrnTQM principles. Results of Interview questions about the benefits and challenges ofrnpracticingTQM, shows that all the respondents agree that it makes dramatic change on thernway things done throughout the organization. Besides the change process starting form Toprnmanagement down to all employees of the organization was too hard to adopt at that time.rnThere were some uncertainties, higher costs and higher turnover of employees, who gets itrnhard to adapt the new paradigm shift towards new philosophy, was the main challenges thernorganization face during the early stage of practicing TQM system. Review of companyrndocuments also show that the company is showing progress through time to time after startedrnpracticing TQM system.