Background: Menstrual hygiene management is a neglected and silent issue especially amongrncommunities in which talking about menstrual hygiene, is taboo in their culture. Women in ruralrnsettings particularly in schools suffer from stigma and lack of services and facilities to help themrncope with the physical and psychological pains they undergo during their menstrual periods.rnObjective: To assess knowledge, practice, and associated factors with menstrual hygienernmanagement among Mekdela secondary school girls, Amhara region, Northeast Ethiopia, 2020.rnMethod: School-based cross-sectional study was conducted among Mekdela secondary schoolrngirls. A total of 441 study participants were recruited. A stratified and simple random samplingrntechnique was used to select study participants. Data was collected using a pretested structuredrnself-administered questionnaire. Data were cleaned, coded, and entered into Epi-data versionrn4.6 Software, and then exported to Statistical package for social sciences version 25 forrnstatistical analysis. Variables with a p-value