Background: Understanding the health related quality of life in people living withrnHIV/AIDS has become increasingly a key measurement of treatment outcome rnPurpose: This study was intended to assess the health related quality of life (HRQQL)rnof people living with HIV/AIDS in Hawassa University Referral Hospital by using thernWilson and Cleary model.rnMethods: Using a cross-sectional design and convenience sampling method, arnquantitative exploratory survey was conducted on HIV patients attending the ARTrnclinic (n=392). Using pretested questionnaires the data collected on demographic and rnclinical characterist ics, symptom status, and patientsâ€™ perceptions of quality of life were rnorganized based on the Wilson and Cleary framework for analyzing variables related tornquality of life. Then, by using SPSS for Windows version 15 a hierarchical multiplernregressions was conducted with quality of life as dependent variablernResult: The sample of 392 persons was 259(66.1%) female with mean age ofrn32.5(SD=8.6) years .On the day of the interview, few 37(9.4%) individuals presentedrnwith opportunistic infections(OI).Similarly the average types of symptoms, out of thernpossible 64 symptoms, experienced per person on the date of visit was 4(SD=4.5).rnTwenty three predictor variables explained 65.1% of the variance in patientsâ€™ overallrnquality of Life. Those participants with higher health related quality of life scores werernthose who had greater functioning, fewer financial worries, lower symptom intensity,rnwith fewer health worries and had no opportunistic infection. In addition social supportrnand disclosure worries made statistically significant relationship with HRQOL at Pvaluernlessrnthanrn0.05.rnrnConclusion:rnThernWilsonrnandrnClearyrnmodelrnofrnqualityrnofrnlifernservedrnasrnarnusefulrnorganizingrnrnframeworkrnrnfor developing an understanding of the correlates of quality of life for arnsample of persons living with HIV/AIDS in Hawassa University Referral Hospital.rnHealth related quality of life for this sample was primarily defined as over all functionalrnabilities, absence of financial worries, control over symptom intensity, lack of healthrnworries and also absence of opportunistic infections. These findings are similar withrnfinding studied both in developed and developing countries. Based on the finding of thisrnstudy, recommendations are forwarded.