Background: -Cervical cancer is considered as a leading cause of morbidity and mortality amongrnfemales worldwide. Human papillomavirus (HPV) is a highly prevalent sexually transmittedrninfection associated with increased cancer risks. Effective HPV vaccines are recommended forrnfemales in the adolescent years, but uptake has been less than optimal. Objective: - To assessrnHPV knowledge, perception and willingness to receive vaccination among female students inrnAddis Ababa University, Addis Ababa, Ethiopia, 2022. Method: - Institutional based convergentrnmixed method was applied. The data were collected from February 7 to April 15, 2022. A total ofrn398 female students were recruited for quantitative and 12 for qualitative study and data saturationrnwas used as a guide to decide number of participants. Multi stage sampling technique was used tornselect study participants. The data was entered into Epi Data version 4.6. and analyzed using SPSSrnversion 25 (quantitative data) and thematic analysis (qualitative data). Bivariate and multivariablernlogistic regression analysis were used to determine associations of variables. Result: - In thisrnstudy, 161(41%) of the students had good knowledge, 226(57.5%) had more favorable perceptionrnregarding to HPV and its vaccine and 30% of the respondents were willing to receive the vaccine.rnYear of study, having history of sexual intercourse, having family history of vaccination andrnperception towards HPV and its vaccine were factors associated with studentsâ€™ willingness tornreceive the HPV vaccine. Misconception about HPV vaccine and lack of awareness about healthrnrisk associated with HPV were identified as factors that hinder students from receiving the vaccinernin qualitative study Conclusion and recommendation: - Considering poor knowledge of HPVrnand its vaccine and willingness of the students to receive the vaccine, educational programs arernrequired to aware female students in Ethiopia about HPV and related diseases as well as its vaccine.rnInclusion of HPV vaccine in national immunization program which is in line with WHOrnrecommendation should be considered as 118(30%) of the participants show willingness to getrnvaccinated.