Helicobacter Pylori Infectionamong Dyspeptic And Non-dyspeptic Hiv Patients At Yekahealth Center Addis Ababa Ethiopia

Background: Helicobacter pylori is a potent producer of urease. HIV infected patientsrnexperience many form of opportunistic infections including gastrointestinal symptoms. The exactrnrole of H. pylori infection among HIV infected patients in causing gastrointestinal symptomsrnsuch as dyspepsia remains unclear. There are limited data regarding H. pylori infection in HIV-rnpositive patients in relation to CD4 count in our region and country.rnObjectives: To assess the prevalence of Helicobacter pylori infection using stool antigen amongrndyspeptic and non -dyspeptic HIV patients at Yeka health center, Addis Ababa, Ethiopia.rnMethods: A case control study enrolling 370 study participantswas conducted from January-rnJune 2017. Socio-demographic and clinical data were collected and3 milliliter blood was drawnrnaseptically for CD4+T cell count and complete blood count. Stool samples were collected forrnH. pylori stool antigen test. All necessary data were recorded on questionnaires and data sheet.rnData entry and analysis was done using SPSS version 20.Logistic regression analysis was used tornsee the relation between dependent and independent variables.rnResults: Of the 370 (185 dyspeptic and 185 non-dyspeptic) study participants, H. pyloriantigenrnwas detected in 117 (31.62%) participants. The prevalence of H. pylori infection was slightlyrnhigher in dyspepsia patients 60/185 (32.43%) than non-dyspepsia 57/185 (30.81%) individualsrn[AOR=1.097, 95% CI: 0.689-1.747, p=0.697]. The infection was significantly associated withrngender in non dyspepsiapatients [AOR=2.612, 95% CI: 1.338-5.099, p=0.015] whilein non-rndyspepsia patients the association was not significantly [AOR=0.805, 95% CI: 0.393-1.648),rnp=0.639]. In both patient groups, no significant association was observed in the prevalence of H.rnpylori with age, family size, educational status, marital status, toilet use habit, occupation,alcoholrndrinking, cigarette smoking and khat chewing (p>0.05). In both case and control group H.pylorirninfection was higher in patients with CD4T cell count greater than 200cells/μl.rnConclusion: The prevalence of H. pylori infection was slightly high among symptomatic thanrnnon-symptomatic patients. The infection was not significantly associated with socio-rndemographic and behavioral factors while it was higher in patients with higher CD4 T cellrncount.The observed prevalence of H. pylori stool antigen positivity necessitates the need torndesign and apply intervention measures that could decrease transmission and thus minimize thernclinical consequences of infection.rnKey words: Dyspepsia, Non-dyspepsia, Helicobacter pylori, Prevalence, Stool Antigen Test

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