Association Of Helicobacter Pylori Infection With Atopy And Allergic Disorders In Ziway Central Ethiopia

Background: Some epidemiological and experimental data point to the protective effect ofrnHelicobacter pylori infection against the development of many extra-gastric diseases,rnincluding gastroesophageal reflux disease and its associated outcomes, childhood asthma andrnallergy. There is scarcity of data concerning this in Ethiopia.rnObjective: To assess the association of Helicobacter pylori infection with atopy and allergicrndisorders in Ziway, Central EthiopiarnMethods and materials: Health facilities and school based cross sectional study wasrnconducted from October 2016 to January 2017, Ziway, Ethiopia. A total of 461 children werernenrolled in the study. Participant‟s socio-demographic and clinical information was collectedrnusing International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Skinrnprick test was done; blood and stool samples were collected from each participant.rnAutomated WBC and manual eosinophil count were performed from EDTA blood while totalrnserum IgE, H. Pylori stool antigen test and serum antibody test were determined using ELISArntechnique. Descriptive statistics were used to express the socio-demographic characteristicsrnof the participants. Binary logistic regression was computed to assess association betweenrnvariables using SPSS version 20 for windows. P < 0.05 were taken as statistically significant.rnResults: The overall prevalence of past and current H.pylori infection was 70.3% and 5.2%,rnrespectively. The overall prevalence of any sensitization was 2.4%. Our result also did notrnshow the protective effect of the bacteria. There was no association between past H.pylorirninfection and atopic sensitization and allergic conditions (OR 1.58, 95% CI 0.44, 5.70rn(P=0.48) and OR 0.96, 95% CI 0.56, 1.62 (P=0.86), respectively) and the current infection ofrnH. pylori was not associated with allergic conditions with OR 1.81, 95% CI 0.53, 6.22rn(P=0.35). In this study the IgE levels were elevated in current H.pylori infected atopicrnparticipants.rnConclusion: In this study we didn‟t find any significant association between past and currentrnH.pylori infection with atopy or allergic conditions. Further studies with high qualityrnlongitudinal cohort are needed to map every possible correlates of the infection.rnKeywords: Helicobacter pylori, Atopy, Allergy, IgE

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