Background: An ocular infection is public health problem in developing countries likernEthiopia. Bacteria are major causative agents that frequently cause infections in the eyes andrnpossibly lead to loss of vision. Resistance of bacteria isolated from the ocular tornantimicrobial agents is a Global concern. Thus the present study will provide essentialrninformation on the prevalence of bacterial infection and antibiotic susceptibility pattern ofrnbacterial isolate. The result of the study will help to formulate a policy for treatment andrnprevention of external ocular infections.rnObjectives: To assess bacterial profile and antimicrobial susceptibility pattern of externalrnocular infections with its associated risk factors in ALERT Center, Addis Ababa Ethiopia.rnMethods: A cross sectional study was conducted from May, 2015 to August, 2015. A totalrnof 288 samples were collected and inoculated on Blood agar, Chocolate agar, MacConkeyrnagar and Mannitol salt agar. Presumptive isolates were further identified by a series ofrnbiochemical tests. Antimicrobial susceptibility pattern was performed for all isolated bacteriarnaccording to the criteria of the Clinical and Laboratory Standard Institute (CLSI, 2014) byrndisk diffusion method. Data were analyzed using (SPSS) version 20.0 software.rnResults: A total of 288 patients were enrolled. From the total of external ocular infectionsrncases, bacterial origins were isolated among 59.4% (n=171/288). The majority of the studyrnsubjects were males 53.1% (n=153/288). Gram positive bacteria were the most dominantrnisolate accounting 70.2% (n=120/171). The most frequent pathogens isolated were S. aureusrn36.8% (n=63/171), followed by Coagulase negative Staphylococci (CoNS) 31.6%rn(n=54/171). Most of the bacteria isolated showed high resistance to Penicillin 91.6% andrnTetracycline 70.6% while, Gentamicin 94% was the most effective antibiotic against Gramrnpositive and Gram negative bacteria. The overall prevalence multiple drug resistance wasrn93% (n=159/171) Gram positive 97.5% (n=117/120) and Gram negative 82% (n=42/51).rnMost of the variables were not statistically significant except for repeated infection.rnConclusion: The prevalence of bacterial pathogens among external ocular samples was high.rnMost of the isolates were drug resistance for commonly used antibiotics. Gentamicin andrnCiprofloxacin was the most effective antimicrobial agents for both Gram positive and Gramrnnegative bacterial from external ocular infections