Introduction: - Wound infections are associated with increased morbidity and mortality.rnEtiologic agents of wound infections vary with geographical locations. Pathogens that infectrnwounds can be part of normal flora or acquired from the hospital environment.rnObjectives: The aim of this study was to investigate the profile of pathogens cultured fromrninfected wound and determine their antimicrobial resistance pattern to commonly prescribedrnantibiotics.rnMethods: prospective cross sectional study was conducted at ARFTH from December 2013 tornMay 2014. Swabs from different types of wounds were processed to investigate etiologic agentsrnusing standard microbiological technique. Antimicrobial susceptibility tests were done using discrndiffusion technique as per the standard modified Kirby-Bauer method.rnResultrnOut of 300 wound swab samples analyzed, 205(68.3%) were culture positive. 33 (16.1%) of thernculture had double infections. and total 238 bacteria were isolated from 205 cases..rnStaphylococcus aureus was the most frequently isolated pathogen which accounted for 91rn(38.2%) of isolates followed by Pseudomonas aeroginesa 53 (22.3%). The sensitivity rates ofrnnorfloxacin, gentamicin and ceftriaxone were 82.8%, 78.9%, and 76.9% respectively. Thernoverall MDR (resistant to three or more antibiotics) rate of gram positive bacteria were 73.6%rnand 67.6% of the gram negative bacterial isolates were identified as multiple drug resistants.rnConclusionrnS. aureus and psuedomonas aeroginesa were the predominant causes of wound infections.rnnorfloxacin Gentamicin and ceftraxone were the most effective drugs. Periodic surveillance ofrnthe species of bacteria involved in wound infection and determination of their antimicrobialrnresistance is recommended for empirical treatment.rnKeyword wound infection, bacterial profile, drug resistance pattern