Background: Leprosy is an old chronic infectious disease that continues to be an importantrnpublic health problem in several developing countries.Host immunologic factors contribute to thernclinical outcome in leprosy. This infection is also accompanied by several alterations in lipidrnmetabolism and changes inthesynthesis of a number of acute phase proteins.rnObjective: To assess the immunological and lipid profile of leprosy patients across the diseasernspectrumrnMaterial and Methods: A crossectional study was conducted at ALERT center which includedrn30 leprosy patients and 21 healthy controls. An 8 ml of blood sample was collected from30rnpatients and 21 healthy controls and used for immunological and lipid profile assays. Aboutrn200Î¼l of whole blood was stained with antibody conjugated flourochromes and data acquisitionrnwas done on FACSCanto II flowcytometer. Lipid profile and C reactive protein tests have beenrndone using chemistry analyzer and qualitative test respectively. Mann-Whitney U test were usedrnto analyze Memory T cells and lipid profile analysis.rnResult:The percentage of memory T cells (CD45RO+) expressed on CD3+ was significantlyrnhigher in PB patients than MB patients. Activated T cells (CD62L-) expressed on CD4+ werernsignificantly higher in PB patients than in MB patients. MB patientâ€™s CD3+ effector T cells werernsignificantly higher than the healthy controls. PB patients showed significantly higher CD3+,rnCD4+ and CD8+ effector memory cells than MB patients. Regarding the lipid profile it showedrnthat, healthy control serum total cholesterol level was significantly higher than MB patients. Onrnthe contrary serum HDL level was significantly higher in healthy control than MB patients.rnConclusion: This study provides further evidence that there is a significant difference in lipidrnprofile among leprosy spectrum. The percentage of both activated and memory T cells in MBrnpatients are significantly lower than in PB patients and this confirms the unresponsiveness of Trncells in MB patients regardless of the high bacterial load in these patients.rnRecommendation:We recommend that monitoring and regulate the lipid homeostasis of leprosyrnpatients may be useful. We also recommend further study on host immune responses in leprosyrndiseases in which lipid metabolism and inflammation intersect