Preliminary Investigation On Immune Response Of Schistosoma Mansoni In Grivet Monkeys (cercopithecus Aethiops Aethiops) Infected With Different Cercarial Doses

In order to evaluate grivet monkey (Cercopithecus aethiops aethiops) as anrnanimal model for the immune response of mansonian schistosomiasis, groups ofrnthree or four grivet monkeys were exposed individually to 100, 200, and 300rncercariae per monkey. Infection and clinical manifestations were observed; EPGrnof stool was determined and different cytokines (IL-12, IFN- , TNF- , IL-4 andrnIL-10) were measured. Infected monkeys began to release eggs 7 weeks postrninfection. Most of them became ill 7 to 9 weeks after initial exposure and exhibitrnmost of the clinical manifestations typical of human acute schistosomiasis. Thernfecal egg count confirmed there is significant (P

Get Full Work

Report copyright infringement or plagiarism