Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) remains a major global healthrnproblem. More than three-quarters of HBV infections occur in Asia, the Middle East and Africa.rnHCV causes an acute and necroinflamatory disease of liver. Blood serves as a vehicle forrntransmission of blood-borne pathogens including hepatitis viruses. Determination of thernprevalence of HBV and HCV in a population in general, and blood-donors in particular willrncertainly help in reviewing the screening procedures and making health policy decisions.rnObjective: The study aims at investigating the seroprevalence of HBV, HCV and associated riskrnfactors among healthy adult blood donor in Wolaita Sodo Hospital, and Christian hospital, WolaitarnZone, Ethiopia.rnMethod: A cross-sectional study was conducted to determine the seroprevalence of HBV andrnHCV infections among blood donors at Wolaita Sodo Hospital, and Christian hospital, WolaitarnZone, Ethiopia. The blood samples were screened for HBV and HCV. All serum samples wererntested for HBsAg and anti-HCV using rapid screening kit method according to the manufacturerâ€™srninstruction. The socio-demographic characteristics and associated risk factors of blood donorsrnwere assessed using structured questionnaire.rnResults: A total of 148 blood donors were tested .The mean age of study participants was 28.8rnyears Â± 5.8.The overall prevalence of HBV and HCV were 10.1% (15/148) and 8.8% (13/148)rnrespectively. The risk factors associated with significant association was observed in sharp injuryrnand teeth extraction for HBsAg (p=0.036 (OR=4.06) and p=0.035 (OR=3.36)).rnConclusion: Screening blood donors for both HBC and HCV is indispensable for safe bloodrntransfusion. It is important to screen donated blood with highly sensitive and specific tests and torncounsel donors who are positive to any of the above infections. It is absolutely necessary to avoidrnthe further transmission of infection.rnKey words: Hepatitis B virus, Hepatitis C virus, Prevalence, Blood donors