The Relationship Between Perinatal Factors And Thyroid Stimulating Hormone (tsh) Level In Newborns Cord Blood In Tikur Anbessa Hospital
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Background: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency presentrnat birth. Untreated, CH has deleterious effects on growth and development of infants. Thyroidrnstimulating hormone (TSH) is used as a compulsory newborn screening assay to evaluate forrncongenital hypothyroidism.rnObjective: The main objective of this study was to assess the relationship between perinatalrnfactors and TSH level in the newborns cord blood.rnMaterials and Methods: A cross sectional study was conducted in Tikur Anbessa Hospitalrnfrom November 26, 2014 - January 26, 2015. Perinatal factors such as body birth weight (BBW),rngestational age, newborns sex, maternal age, parity, pregnancy induced hypertension, gestationalrndiabets and 1st & 5th minute apgar score were documented. Five ml of blood was drawn fromrnumbilical cord, centrifuged and analyzed for thyroid profile using enzyme-linked immunosorbentrnassay (ELISA). The perinatal factors were compared with cord blood TSH level. Differencesrnwere considered statistically significant when p
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