Background: Bacterial meningitis is one of the most serious infectious diseases. The most frequentrncauses of meningitis are Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilusrninfluenzae. The infection usually associated with a high rate of complications. Data on the recentrnrelative magnitude of the bacterial isolation and their antibiotic susceptibility patterns is insufficientrnin Ethiopia.rnObjectives: The aim of the study was to determine etiological agents of bacterial meningitis atrnUniversity of Gondar Teaching Hospital and assess their antibiotic susceptible pattern during last 5rnyearsrnMethods: This is a retrospective analysis of three thousand and eighty five cerebrospinal fluidrnspecimens submitted to the bacteriology laboratory of Gondar University Hospital for culture andrnantibiotic susceptibility patterns in a period between January 2006 and December 2010. The studyrnwas done from November 1, to December 31, 2010.rnResults: For this retrospective study data were obtain from 1589 males and 1496 females makingrnmale to female ratio 1.06:1 of suspected cases of meningitis in Gondar University Hospital. Thernetiological agent had been identified in 120 (3.8%) of the total 3085 CSF samples by culture. Thirty-rnnine (32.5%) of them were infants below the age of 12 months. Streptococcus pneumoniae was thernpredominant pathogen accounting for 52 (43.3%) of the cases. Whereas Neisseria meningitidis andrnHaemophilus influenzae accounted for 27(22.5%), and 12(10%) respectively. Other gram negativernbacilli and Staphylococcus aureus were isolated from 21(17.2%), and 11(9.2%) cases respectively.rnAmong gram positive organisms S.pneumoniae showed a high level of drug resistance against co-rntrimoxazole 44(84.3%), tetracycline 17(32.6%), gentamicin 10(19.2%) chloraphinicol 4(7.6%) andrnampicillin 3(5.7%). Among gram negative bacteria, N.meningitidis was found to be resistant to Co-rntrimoxazole in 25(92.5%), Chloraphinicol 2(7.5%), Gentamicin 4(14.8%) and Ampicillin 4(14.8%).rnE. coli and salmonella spp. were found to be resistant to most antibiotics except ciprofloxacin. BothrnS. Pneumoniae (7.6%) and S. aureus (18.1%) were found to be resistant to ciprofloxacin. Multiplerndrug resistance was observed in 58.3% of the isolates.rnConclusions and recommendation: Streptococcus pneumoniae remains the major aetiologicalrnagent of Community Acquired Acute Bacterial Meningitis (CAABM) both in adults and children inrnthe study area. 5.7% of Streptococcus pneumoniae were resistances to penicillin. Further researchrnshould focus on preventable aspects CAABM of, especially pneumococcal vaccines, to reduce therndisease burden.rnKeywords: bacterial meningitis, antimicrobial susceptibility and pyogenic meningitis.