Schistosoma Mansoni Infection And Response Rate For Praziquantel In Pre-school Aged Children Attending Erer Health Center Somali Regional State Eastern Ethiopia

Background: Intestinal schistosomiasis is one of the most widespread parasitic infections inrntropical and subtropical countries. In sub-Saharan Africa, the recommended strategy to controlrnschistosomiasis is preventive chemotherapy. Though World Health Organization (WHO)rnrecommends praziquantel for the control and treatment of schistosomiasis, Pre-school aged childrenrn(PSAC) are excluded from population treatment programs mainly due to paucity of data onrnresponse rate.rnObjective: The aim of this study is to assess the magnitude of Schistosoma mansoni infection andrnresponse rate to praziquantel treatment in pre-school aged children (≤ 5 years of age).rnMethods: Facility based prospective study was conducted between April to June 2016 at ErerrnHealth Center, Eastern Ethiopia. Stool sample was collected and examined with double Kato-Katzrnfor two consecutive days from children attending the health center and repeated after four weeks ofrnpost-treatment from those who had been infected with S. mansoni. Response rate of praziquentelrnwas assessed after treatment with praziquantel at a single dose of 40mg/kg given by healthrnprofessionals at health center. Interview was used to assess socio demographic background andrnclinical data. Data analysis was performed using SPSS version 20. Bivariate and multivariaternanalysis was performed to test statistical association of dependent and independent variables.rnResults: The prevalence of S. mansoni among PSAC was 25%. The result showed a 96.4% curernrate and 99.4% egg reduction rate four weeks post treatment resulting in good response rate. Age ofrnchildren and frequency of taking children to the river was significantly associated with S. mansonirninfection. The more often children were taken to river during fetching water also associated to S.rnmansoni infection with (AOR=3.86).rnConclusion: This study reveals that treatment of S. mansoni infection with praziquantel shows goodrnresponse in pre-school children. Thus, it is recommended that FMOH should include pre-schoolrnchildren in S. mansoni endemic areas in mass de-worming campaign through administeringrnpraziquantel.rnKeywords: Schistosoma- mansoni, Praziquantel, response rate, pre-school children.

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