Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by severe pain of joints and swelling, joint damage and disability which leads to joint destruction and loss of function with unknown etiology. According to global burden of 2010 study, prevalence of 0.24%, rheumatoid arthritis is ranked among the top 15 of diseases causing disability worldwide. The complication of RA is related to cardiovascular diseases. The morbidity and mortality is related to systemic inflammation and dyslipidaemia. rnObjective: The general objective of this project is to assess serum lipid profiles and high sensitivity C-reactive proteins among patients suffering from rheumatoid arthritis and attending in Tikur Anbessa Specialized Hospital ( TASH ), Addis Ababa, Ethiopia. rnMaterial and Methods: Hospital based cross sectional comparative study was conducted to assess serum lipid profiles and high sensitivity C-reactive protein on rheumatoid arthritis patients in RA clinic at TASH. Patients who came to TASH during the study period were selected by convenience sampling method until the required sample size was achieved. Data was cleaned manually, coded, entered and analyzed by SPSS version 20. Written consent was obtained for willingness of patients to participate after getting official permission letter from Addis Ababa University and then from respective selected rheumatoid arthritis clinic. rnResult: The result of this study demonstrated that there was significant elevation of mean Â± SD of TC, TC/HDL, LDL/HDL and lowered value of HDL-C was seen among RA patients than controls (P-value < 0.05). The mean Â± SD of inflammatory marker, hsCRP was significantly higher among rheumatoid arthritis patients compared to controls (P value