Due to their environment friendliness, natural abundance of the fibers, lower weight and cheaprnproduction cost, natural fiber reinforced composites are being used in different application areas.rnProperties of this material depend on many factors such as fiber reinforcement structure, loadingrncondition, and fiber orientation and so on. In this paper, the effect of fiber orientation on the fatiguernreaction of sisal reinforced epoxy composite is investigated. Sisal fiber is manually extracted andrnprepared. The fiber-matrix weight composition can be taken in different ways. But, due to its betterrnmechanical property result and excellent performance, the weight ratio of sisal fiber to epoxy resinrnis taken to be 30/70. With a hand-lay-up method, sisal reinforced epoxy composite is produced inrn[0rn0rn0rn]2 and [Random] fiber orientation and comparisons are made on their static andrnfatigue reaction. Several specimens, from each group are subjected to static and cyclic loading usingrnInstron machine (Model 4483) with three-point bending test system. From the result, it is found thatrnthe [0rn0rn,90rn0rn]2, [0rn,45rn0rn0rn]2 fiber orientation resulted in a better flexural property such as transversal load capacity,rnflexural strength and modulus of elasticity. And [0rn,45rn]2 fiber orientation exhibits better fatigue lifernwith the [0rn0rn0rn,90rn0rn]2 orientation scoring the lowest life at about 2/3 of the life of the former. Thernrandomly oriented specimens have the lowest flexural property but better fatigue reaction than thatrnof [0rn0rn,45rn0rn0rn,45rn]2 specimens.