Introduction: Hypertension is a single most important risk factor for cardiovascular disease,rnand the growing public health issue in developing countries. It has been reported thatrninappropriate acute thrombus formation (hypercoagulability) is the pathophysiologicalrnsubstrate underlying increased risk and severity of target organ damage of hypertension, suchrnas acute coronary syndrome and stroke that can cause significant morbidity and mortality. Plasma D-dimer level has been reported to be a good biochemical marker of thrombosis. rnObjectives: The objective of this study was to assess plasma D-dimer level and its correlationrnwith disease severity among hypertensive patients at Yikatit 12 Hospital Medical College.rnMethods: A hospital based comparative cross-sectional study was conducted at Y12HMC.rnHundred participants (60 hypertensives and 40 controls) were recruited in the study. Datarnwere collected using structured questionnaire through face to face interview, reviewingrnmedical records and direct measurement of variables. The data was analyzed using SPSSrnversion 25.0 and categorical variables were described by frequency and percentage whilerncontinuous variables by mean and standard deviation. The association and correlation betweenrnvariables were determined using correlation coefficients, regression analysis, and also usingrndifferent parametric and non-parametric tests accordingly. rnResults: Among study participants, female to male ratio was 1.4 and the mean age was 52rnyear with a range of 20 to 80â€‰years. Among hypertensives,30(50.0%) were in stage 1 whilern14(23.3%) and 16(26.7%) were in stage 2 and severe hypertension respectively. We observedrnhigher D-dimer levels among hypertensives when compared with the healthy controlsrn(p