Chemotherapy is long been recognized that a well- established therapeutic approach for severalrnmalignancies including breast cancer. But the clinical efficacy of this drug is often limited by itsrnrelated cardio toxicity. The assessment of multiple cardiac biomarkers can be used in identifyingrnpatients at increased risk and adverse outcomes from chemotherapy. This approach hasrnsignificant importance to predict which patients will have adverse cardiac effects fromrnchemotherapy as well as treat damage at an earlier stage, preserve patient health, and improvernquality of life.rnObjective: The aim of the present study was to evaluate changes in cardiac and inflammatoryrnbiomarkers level following chemotherapy treatment among female breast cancer patientsrnattending at Tikur Anbessa specialized hospital .rnMaterials and methods: Hospital based retrospective study was conducted in 40 female breastrncancer patients at TASH. Elecsys 2010 Troponin-T immunoassay analyzer ( to measure serumrncTnT level ), Roch/hitachi cobas c 502 analyzer ( to measure serum CKMB and CRP levels)rnand R and D systemic luminex performance assay( to measure serum IL-6 and TNF- ï¡)werernused in 40 paired breast cancer patient samples retrieved from a repository specimen of anrnongoing thematic research project. Data were analyzed using SPSS software version 23 packagernand a p value < 0.05 was considered statistically significant.rnResults: In the female breast cancer patients receiving chemotherapy treatment, the mean serumrncTnT, CKMB, CRP and TNF-ï¡ï€ levels were significantly increased than their respective baselinernvalues. No significance difference was found in the level of IL-6 between the base line andrnduring chemotherapy treatment. 20%, 15%, 14% of the breast cancer patients had elevated cTnT,rnCK-MB and CRP levels after the three cycles of chemotherapy treatment respectively and 15%rnof patients had a baseline elevated levels of CRP compared with their respective cutoff value.rnConclusion: Cardiac biomarkers are significantly increased up on chemotherapy treatment