Bacterial Urinary Tract Infection Among Adult Renal Transplant Recipients At St. Pauls Hospital Millennium Medical College Addis Ababa Ethiopia

Background: Although significant advances have been made in surgical techniques andrnimmunosuppression for renal transplantation, urinary tract infections continue to be a major publicrnhealth problem globally. Post-transplantation urinary tract infection complications includingrnasymptomatic bacteriuria, cystitis, and pyelonephritis are the most common form of bacterialrninfection following renal transplantation. It could result in graft function impairment and death. rnObjectives: The study aimed to investigate the prevalence of bacterial isolates that cause urinaryrntract infections, assess antibiotic susceptibility pattern among symptomatic and asymptomatic renalrntransplant recipients attending for health care at St. Paul’s Hospital Millennium Medical College. rnMaterials and Methods: A hospital-based cross-sectional study was carried out from Decemberrn2017 to August 2018 among 74 renal transplant recipients. The sociodemographic characteristicsrnwere collected using structured questionnaires. A first morning voided clean-catch mid-stream urinernspecimens were collected and 0.001ml inoculated onto a blood and MacConkey agar plates followingrnthe standard bacteriological protocols. It was incubated aerobically at 35–37°C for 18–24 hours.rnCultural characteristics and series of biochemical tests were used for identification. rnResults: Significant bacteriuria was found in 11/74 (14.9%), 95%CI =8.2-24.7) of the patients. Thernprevalence among females 6/32(18.75%) was higher than males 5/42(11.9%) without significantrnassociation (COR=2.09, 95%CI=1.04-8.45, P=0.253). UTI was higher in the age group between 35–rn49 years old (19.3%. Age was statistically significant and stronger independent associated risk factorrnwith crude odds ratio=3.67, 95%CI=2.89-20.07 and 0.003, respectively. The most prevalent bacteriarnisolates were Escherichia coli 2(18.2%), Staphylococcus aureus 2(18.2%), Acinetobacter spp.rn2(18.2%), Enterococcus spp. 2(18.2%), Coagulase-negative Staphylococci 2(18.2%)] followed byrnPortus mirabilis 1(9.1%).The majority (80%) of Gram-negative bacteria were resistant tornciprofloxacin, chloramphenicol, and trimethoprim/sulfamethoxazole. Multi drug resistance patternrnwas shown in 82% of the isolates. rnConclusion and Recommendations: The overall prevalence of UTI in the study was low with arnprevalence of 14.9%. Better to establish routine urine cultures especially in the first 6-12 months.

Get Full Work

Report copyright infringement or plagiarism