Histopathological Characteristics And Immunohistochemical Biomarkers Of Invasive Breast Cancer In Ethiopia Women

Background: Breast cancer has been shown as commonest type of cancer in Ethiopian women.rnIt is a heterogeneous disease in terms of clinical, histopathological and biologicalrncharacteristics. Some of the molecular differences underlying this heterogeneity werernpreviously discovered by genetic expression profiles and validated by immunohistochemicalrnsurrogates. Hence, this study was carried out to analyze breast cancer by histopathologicalrnfeatures and immunohistochemical markers, and interrelationship among them in Ethiopianrnfemale breast cancer cases. rnMethod: This study was a retrospective analytical study done on clinically and pathologicallyrnconfirmed breast cancer cases that underwent modified radical mastectomy (MRM) from June,rn2014 – June, 2015. The primary breast tumor tissues with the corresponding axillary lymphrnnodes were examined for histopathological features including histologic type, tumor size, nodalrnstatus and grade. Evaluation of the molecular markers including ER, PR, EGFR and VEGF-Arnwere done by immunohistochemistry using formalin-fixed and paraffin-embeded tissues. Datarnwas analyzed using SPSS 24.0. The p value

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