Introduction:Type II diabetes is an alarming rate problem globally and in Ethiopia due tornchange in diatery habits and sedentary life style. Serious complications are associated withrndiabetes, particularly macrovascular and microvascular complications. Early controlling bloodrnglucose significantly reduces the risk of complications of diabetes, but yet no effective cure forrnit, even though available drugs currently used in managing the disease are associated withrnseveral undesirable side effects. Traditional treatment with low cost and minimum side effect isrnused to treat diabetes across the world due to the different types of ingredients present inrnmedicinal plants that act on a variety of targets by various modes and mechanisms. Ethiopia isrnrich in traditional medicinal plants and Persea americana mill is also part of this which peoplerncomsume as food. rnObjectives: In this study the effect of Persea americana mill fruit juice on FBG, weight, LDL-c,rnTG, TC, HDL-c and total protein in HFD/ low dose STZ indued type II diabetes mellitus hasrnbeen evaluated in male albino wistar rats. rnMaterials and Methods: Thirty six male albino wistar rats of 150-200 g weight were divided inrnto six different groups. Except six rats, the rest thirty fed on HFD for one month to inducernprediabetes and insulin resistance, next followed by 35mg/Kg of STZ injection. Group I servedrnas normal control; Group II served as diabetic control; Group III recieved 7mg/Kg of metformin;rnGroup IV, V and VI were given 856 mg/kg, 1712 mg/kg and 2568 mg/kg of Persea americanarnmill fruit pulp juice for six weeks respectivily. The effect of fruit pulp juice on food intake andrnweight was measured by triple beam balance. After forty-five days treatment, the rats werernfasted overnight (12 to 14 hours), anaesthetized and blood sample was collected by cardiacrnpuncture for biochemical tests. Results were analyzed using one way ANOVA at a 5% level ofrnsignificance. rnResults: In higher dose (2568 mg/Kg) of Persea americana mill fruit pulp treated group foodrnconsumption,weight, FBG, LDL-c were signifacantly reduced and HDL-c increased (P