Burden Of Campylobacter Species On Livestock Owning Households In Per-urban Addis Ababaethiopiaa One Health Approach.

Background: Campylobacter is the most common infectious causes of diarrhea and acuterngastroenteritis globally, and has been recognized as a significant zoonotic agent. Numerousrnanimals serve as reservoirs and a potential source Campylobacter species for food, water andrnenvironmental contamination. The rising of antimicrobial resistance amongstCampylobacterrnisolates, is a significant global issue.rnObjective (s): The study was aimed to highlight the importance of livestock, poultry and waterrnin peri-urban Addis Ababa, as sources of zoonotic Campylobacter species and antimicrobialrnsusceptibility of isolated strains.rnMethods: A cross-sectional study was conducted from December 2018 till April 2020 to collectrnand process 519 samples including feces from livestock, poultry, human and water samples formrnlivestock keeping households of the peri-urban Addis Ababa. Data on houeholds’rnsociodemographics, knowledge and practices regarding livestock production was collected usingrna structured questionnaire.rnResults: Of the 519 tested samples, 67 (13%) were positive for Campylobacter species, in whichrn10.1%, 18.5%, 13%, 13.3%, 7.1% and 10.5% were from human, cattle, poultry, sheep, goat andrnwater samples, respectively. Regardless of isolation source, C. jejuni and C. fetus were the mostrnobserved species with the prevalence rate of 17 (25.4%) each. C. coli was isolated only from 6rn(9%) of samples, whereas, none of the tested samples were positive for C. lari. The use of storedrnwater and practices of indoor and outdoor manure collecting, taking any specific protection whilerncleaning animal pen and washing hands before and after cooking were significantly associatedrnwith the human Campylobacter positivity.All (100%)of Campylobacter isolates from human,rnpoultry, sheep, goat and water and 96% of isolates from cattle were resistant to at least one orrnmore of the tested antimicrobials. More importantly, 95.5% the isolates were resistant to three orrnmore classes of antimicrobials.rnConclusion: The study found that multidrug resistant Campylobacter jejuni, coli, fetus and otherrnCampylobacter with unidentified species were prevalent in the study area.Hence, considering thernvery significant effect of antimicrobial resistance, it is important for the country to have arnnational plan to advance the rational use of antimicrobials in the view of “One Health” approach.

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