Background: Celiac disease (CD) is an autoimmune disorder triggered by consuming a protein called gluten. It is determined rnby both environmental and genetic factors. Infection by Helminths and H.pylori are among the environmental factors involvedrnthat enhance anti-inflammatory response. Different auto antibodies and antibodies are used in the diagnosis of celiac disease, butrnAnti-tTG antibodies are highly sensitive and specific for the diagnosis of CD. IgG-based tests are useful for detecting celiacrndisease. Since Celiac disease is one of the areas that did not get much attention in its diagnosis; this study could give some insightrnon the necessity of doing more research in the area and gives a better understanding on the association between celiac diseasesrnwith that of lipid profiles, H.pylori and Helminths infection rnObjective: The objective of this study was to assess anti-tissue transglutaminase IgG antibody with selected lipidrnpanels among H.pylori and Helminths positive and non infected Children. rnMethods: A cross sectional retrospective and prospective study was conducted in Ziway, South east of AddisrnAbaba, Ethiopia by using random sampling method. The retrospective part included taking serum samples that wererncollected and stored during another study and careful review of study groups sociodemographic and medical data.rnThe samples that were kept refrigerated at -80ÂºC were used for analysis of anti tissue transglutaminase IgG and lipidrnprofiles as for the prospective part of the study starting from May 2020 to June 2020. The transglutaminase IgGrnmeasurement used principle of Enzyme immunoassay for optical density measurement based on commerciallyrnavailable kit. While the lipid panels used kinetic assay that were measured on Cobas 6000 fully automated chemistryrnmachine. The obtained data was entered and analyzed by using SPSS version 23 and descriptive analysis, Chisquarernrnand logistic regression were used to see any associations and P-value