Background: The problem of dyslipidemia is high in patients with diabetes mellitus. There isrnknown evidence that abnormalities in lipid metabolism are important risk factors for increasedrnincidence of diabetes associated complications. The most important risk indicators for theserncomplications are lipid profile abnormalities. Very few published papers have tried to draw arnconclusion about khat chewing and it effect on lipid level. However, the influence of chewingrnkhat on the lipid profile and dyslipidaemia is insufficiently investigatedrnObjective: This study aimed to assess lipid profile among diabetic and apparently healthyrnsubjects with and without khat chewing habit.rnMethod: a comparative crossectional study was conducted in Adama. A total of 220(118 DMrnand 102 apparently healthy) study subject were included. Convenience sampling methods werernused. Basic anthromotric and demographic data was collected using structured questionnaires.rnAnd Serum Lipid profile was measured using Cobas 311 automated clinical chemistry analyzerrnat Adama hospital. Data were analyzed statistically using spss version 20.0. Independent t testrnwere used to compare the means of lipid profile among two groups and logistic regression isrnused to associate lipid profile parameter with different independent variables. P-value