Background: Ascites is one of the most common complications in patients with cirrhosis. rnAscites fluid infections are common and potentially life-threatening infections frequentlyrnencountered in patients with cirrhotic ascites. The diagnosis of ascetic fluid infections is basedrnon the number of polymorph nuclear neutrophil (PMN)) cells and the result of ascetic fluidrnculture. rnObjective: The main objective of this study was to evaluate the pattern, clinical andrnmicrobiological profile of Spontaneous ascites fluid infection (SAFI), in patients with liverrncirrhosis attending at selected public hospital from March 2020 to March 2021. rnMethods: Hospital based cross sectional study was conducted from March 2020 to March 2021.rnSaint Paul Specialized Hospital and Yekatit 12 hospital medical colleges were chosen byrnpurposive sampling method. Cirrhosis patients with ascites who presented to the hospitals werernconveniently enrolled and consecutively recruited. Structured questionnaire was used to collectrndemographic data, clinical diagnosis and laboratory investigation. Culture and drug resistantrnpattern studied following standard methods. Data was analyzed using statistical software IBMrn(SPSS 23) and multinomial regression analysis was done to assess association between outcomernand explanatory variables. rnResults: 51 out of 218 patients (23.34%) were found to have SAFI, out of which 19 (37.3%)rnwere female and 32 (62.7) were male. 40 (78.43%) patients had Culture Negative Neutrocyticrnascites (CNNA), 11 (21.57 %) had Classic SBP (Spontaneous bacterial peritonitis) and 1 (2.0%)rnhad Bacterascites. Gram negative (mainly Escherichia coli n=4 (36.36%), and Klebsiellarnpnuemoniae n=3 (27.27%)), and Staphyloccus aureus n=1 (9.09%), Streptococcus viridans n=1rn(9.09) and CoNs (coagulase negative staphs) n=2 (18.27) . Most identified E.coli were resistantrnto Ceftriaxone. Abdominal distension (62%), pedal oedema (60%), abdominal pain (62%) andrnjaundice (52) were the main clinical features in those with SAFI. History of jaundice, fever, lowrnserum Albumin, high ALT, and low Ascites fluid albumin were among independent predictors. rnConclusion: Spontaneous Ascites fluid infection (SAFI) was common among cirrhotic patientsrnwith ascites attended at SPSHMMC and Yekatit 12 hospital medical college. Jaundice, low rnarterial blood pressure, low platelet, low serum albumin, and low Ascites fluid albumin were amongrnhighly indicative SAFI and diagnostic paracentesis should be done instantly on admission to confirm therndiagnosis preferably before starting empiric antibiotic therapy to enhance culture positive rate.