Prevalence And Drug Susceptibility Pattern Of Group A Streptococcus Among Patients With Tonsillopharyngitis Attending Yekatit 12 Hospital Addis Ababa Ethiopia

Background: The group A streptococcus causes different spectrum of human infections, ranging from rnpharyngitis and pyoderma, to life threatening immunological complications such as acute rheumatic fever,rnrheumatic heart disease, post streptococcal glomerulonephritis, toxic shock syndrome and necrotizingrnfasciitis. The greatest global burden of group A streptococcus disease is due to Rheumatoid Heart Diseasernwhich follows group A streptococcus pharyngitis, where 15 million cases and 349,000 deaths occurrnworldwide.rnObjective: To determine the prevalence, drug susceptibility pattern of group A streptococcus and possiblernassociated risk factors among patients with Tonsillopharyngitis attending Yekatit 12 Hospital, AddisrnAbaba, Ethiopia.rnMethods: A cross-sectional study was conducted on 192 participants with Tonsillopharyngitis whornattended Yekatit 12 hospital Ear Nose Throat clinic in the city of Addis Ababa, Ethiopia from July 2020rnto October 2021 and throat swab sample was collected. A standard microbiological method was used tornisolate and identify group A streptococcus from throat swabs obtained from study subjects. The diskrndiffusion method was used for antimicrobial susceptibility testing. Descriptive statistics and multivariaternlogistic regression analysis were done by Statistical Package Social Science version 26. rnResults: In this study, the overall prevalence of group A streptococcus was 3.65% (7/192).All isolates ofrnGAS were susceptible to all penicillin (10unit), Clindamycin (2µg), Chloramphenicol (30 µg),rnVancomycin (30µg), erythromycin (15 µg), Tetracycline (30 µg) while resistance to Trimethoprimsulfametoxazolernrn(1.25/23.75µg). None of the risk factors were found to be significantly associated withrnstrep-throat Tonsillopharyngitis [P>0.05]. rnConclusion: In this study the prevalence of group A streptococcus was relatively low. All group Arnstreptococcus isolates remained susceptible to penicillin, Clindamycin, erythromycin, Chloramphenicol,rntetracycline and Vancomycin indicating that those are still the drug of choice for the treatment of GASrninfection.

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