Background – Several previous studies indicated conflicting findings on parameters ofrnMetabolic Syndrome and CRP in cigarette smokers. The aim of this study was to determinernwhether there is difference in levels of parameters of Metabolic Syndrome and CRP inrncigarette smokers and non- smokers in Adama, Ethiopia.rnMethods – subjects were 99 healthy male individuals from age 15 to 60 years. The subjectsrnwere divided into two groups of 50 smokers and 49 non- smokers. BMI, blood pressurernplasma levels of total cholesterol, triglycerides, HDL, and CRP were measured and LDLrncholesterol was estimated using the Friedewald formula.rnResults – Overall subjects’ plasma levels of total cholesterol, triglyceride, LDL, HDL andrnserum CRP were significantly elevated in smokers. No significant difference was found inrnBMI, systolic and diastolic blood pressure between cigarette smokers and non-smokers. Inrnsmokers alcohol drinking was significantly correlated with increased plasma HDL, systolicrnand diastolic blood pressure while khat chewing was correlated with increased plasma totalrncholesterol.rnConclusions – The results showed no difference in BMI between smokers and non smokersrnand also there was no significant difference in blood pressure in smokers and non smokers.rnCigarette smoking is correlated with increased total cholesterol, TG, LDL, HDL and CRP.rnAmong smokers blood pressure, total cholesterol and HDL were significantly higher in thosernwhose alcohol consumption was higher.