Antilipidemic Properties Of Calpurnia Aurea Leaf Extract On High Fat Diet Induced Hyperlipidemia Male Albino Wistar Rats

Introduction: Hyperlipidemia is an elevation of the plasma lipids such as triglycerides,rncholesterols, cholesterol esters, phospholipids and/or plasma lipoproteins including very low densityrnlipoprotein and low density lipoprotein, and reduced in the circulating high-density lipoproteinrnlevels. It is associated with an increased risk of coronary heart disease such as atherosclerosis andrnmyocardial infarction.rnObjective: To investigate the antilipidemic properties of hydromethanolic extract of Calpurniarnaurea leafs against high fat diet induced hyperlipidemic male albino wistar rats.rnMethods: Thirty albino Wistar rats’ 60-75days old and weight of 150- 200 grams were dividedrnrandomly in to six groups of five each. Group I served as normal control, group II received high fatrndiet (48.8% fat w/w) containing lard made from beef fat and mixed with hydrogenated vegetable oil,rngroup III received high fat diet supplement with 3.5 mg/kg/day atorvastatin as standard control andrnthe remaining three groups IV, V and VI received high fat diet along with hydromethanolc extract ofrnCalpurnia aurea at (200,300 and 400) mg/kg/day respectively for 60 days. Food intake, Body weight,rnbody mass index, serum lipid profiles and liver histopathology were assessed.rnResults: The result of this study revealed hydromethanolic extract of Calpurnia aurea /HMECArnhave dose dependent antilipidemic activities. Calpurnia aurea treatment of 400mg/kg caused arnsignificant lowering of (p < 0.05) of serum LDL from 28.53±12.2 mg/dl to 9.70 ± 5.77 mg/dL; thernserum Cholesterol level from 92.00± 13.0 mg/dl to 60.33± 8.60 mg/dl; and the serum triglyceridernleve1from 71.83 ± 13.0 mg/dl to 84.73±19.4 mg/dl and on the other hand for the same dose it hadrnsignificant elevated serum HDL levels from 11.66 ±1.23 mg/dl to 29.66± 1.52 mg/dl. At the mediumrndose of 300mg /kg it was not effective as 400mg /kg and at the minimal dose of 200mg/kg broughtrnnumerical difference not statisticaly significant among the serum lipid profile.rnConclusion: These observations suggest that HMECA has a dose dependent antihyperlipidemicrneffect against high fat diet induced hyperlipidemia. The molecular mechanism of antilipidemicrnactivities of this drug need to be studied.rnKEY WORDS: Calpurnia aurea, High fat diet, Hyperlipidemia, Lipid profile, Atorovastatin.

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