Effect Of Green Tea (camellia Sinensis) Leaf Extract On Highly Active Anti- Retroviral Therapy Induced Dyslipidemia And Non Alcoholic Fatty Liver Disease In Albino Wistar Rats

Back ground: Tea is the second widely consumed drink in the world next to water and used byrnpeople in different parts of the world for treatment of different health ailments; especially, green tea.rnHAART which is a recently(since 1996) developed form of ART medication to treat HIV/AIDS isrnnow becoming hepatotoxic to patients and found to be more hazardous to the health of HIV patients.rnObjective: The aim of this study was to investigate the possible remedial effect of GTE on HAARTrninduced derangement of lipid metabolism in albino Wistar rats.rnMaterials and Methods: Thirty female albino Wistar rats 10-12 weeks old and weight of 145-200rngrams were divided in to five groups of six each randomly. Group-I (normal control group) whichrnwere given 1mL of distilled water per day, Group-II (negative control group) which were givenrnHAART only, Group-III (which were given HAART and 100mg/Kg of GTE), Group-IV (which wererngiven HAART and 200mg/Kg of GTE) and Group-V (which were given HAART and 400mg/Kg ofrnGTE) for sixty days. On the 60th day of the experiment rats was fasted overnight and sacrificed byrncervical dislocation after giving di-ethyl ether general anesthesia. Then blood was taken by cardiacrnpuncture for lipid profile investigation and for liver function test. Liver was also taken from eachrnexperimental rat for histopathological evaluation and triglyceride extraction.rnResults: The results of our experiment showed that, the body weight change showed a significantrndecrement (p

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