Hepatoprotective Effect Of Silymarin On Fructose Induced Nonalcoholic Fatty Liver Disease In Male Albino Wistar Rats

Background: Nonalcoholic fatty liver disease is one of the most common causes ofrnchronic liver disease in the Western world, and it‟s likely to parallel the increasingrnprevalence of type 2 diabetes, obesity, and other components of metabolic syndrome.rnThere is also growing evidence in both animal models and human studies suggesting thatrnhigh dietary intake of fructose is an important nutritional factor in the development ofrnmetabolic syndrome and its associated complications of NAFLD. However, an optimalrnparameters in the fructose model group had been partially ameliorated when treated withrnsilymarin.rnConclusion: The rats fed with fructose developed dyslipidemia, oxidative stress and mildrnsteatosis in liver, which are the characteristics feature of nonalcoholic fatty liver disease.rnWhen treated with silymarin showed amelioration in oxidative stress, dyslipidemia andrnsteatosis of liver in some extent but could not reach the normal control values.rnKey Words: Nonalcoholic Fatty Liver Disease, Silymarin; Lipid Peroxidation;rnDyslipidemia; Total Antioxidant Status; Reduced Glutathione.rnrntreatment for NAFLD has not been established. Silymarin is gaining increasingrnrecognition due to its beneficial effects in the control and prevention of alcoholic liverrndisease, acute and chronic viral hepatitis and toxin-induced liver diseases.rnObjective: The current study aim to investigate the hepatoprotective effect of silymarinrnon fructose induced nonalcoholic fatty liver disease in rats.rnMethodology: Thirty male Wistar rats were randomly divided into five groups: normalrncontrol group that consumed tap water; Silymarin control group that consumed tap waterrn+ silymarin (400 mg/kg/day), fructose control group that consumed 20% fructosernsolution; Treatment group that consumed 20% fructose solution + Silymarin (200rnmg/kg/day) and treatment group that consumed 20% fructose solution + silymarin (400rnmg/kg/day). The food and liquid intake, body weight, liver triglyceride, serum lipidrnprofile, lipid peroxidation, antioxidant level and morphological as well asrnhistopathological changes of liver were investigated. The data were analyzed using onernway analysis of variance (ANOVA) followed by tukey multiple comparison test andrnstatistical significance was determined at p ˂ 0.05.rnResult. This study showed that the fructose consumed model group had a significantlyrnhigh values in the stage of steatosis grade, liver weight, hepatic triglyceride, serumrntriglyceride, total cholesterol, low density lipoprotein cholesterol, alanine aminorntransferase, aspartate aminotransferase and hepatic malondialdehyde concentration asrncompared to the normal control and contrariwise a significantly low values of reducedrnglutathione, plasma total antioxidant capacity and food consumption. The altered

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