Background: Intestinal parasitic infections are major public health and socio-economic concernsrnthat adversely affect the well-being of millions of peoples worldwide, mainly the poor inrndeveloping countries. The most prevalent helminthes in developing countries are Schistosomarnmansoni, Ascaris lumbricoides, Trichuris trichiura, hookworms and Hymenolepis species.rnIntestinal Schistosomiasis is a serious public health problem mainly in tropical and subtropicalrnparts of the world.rnObjective: To determine prevalence of intestinal parasites and knowledge, attitude and practicesrn(KAPs) among individuals who have river water contact with special emphasis on Schistosomarnmansoni in Addiremets, Western Tigray, Ethiopia.rnMethodology: A cross sectional study was conducted from February to April 2017. A total ofrn411 study participants were included in this study. Socio demography, associated risk factors andrnknowledge, attitude and practice (KAPs) of individuals regarding intestinal parasitosis mainly tornintestinal schistosomiasis were collected using preformed structured questioners. From all studyrnparticipants, stool samples were collected and laboratory investigations were performed usingrndirect microscopy, Formol-Ether concentration and Kato- Katz techniques. Malacology studyrnwas assessed by collecting snails from the river in the study area. Data was entered into excelrnsheet, cleaned and exported and analyzed using SPSS version 20. Bi-variant logistic regressionrnand multiple logistic regressions were used for correlation analysis.rnResult: The overall prevalence of intestinal parasites was 51.3%. The most frequent parasitesrnencountered were S. mansoni and H.worm. The prevalence was slightly higher among malesrn54.1% (131/242) than females 47.3% (80/169). The highest proportion of parasites was reportedrnamong the age group of 5-9 years old subjects (70.6%). The prevalence of S. mansoni was foundrnto be 26.3 % with mean of intensity infection 218 egg per gram (Range: 24 to 1728). Of all studyrnparticipants 94.4% had good knowledge while 35.9% of them had poor practices towardsrnintestinal parasitosis and intestinal schistosomiasis.rnConclusion: High prevalence of intestinal parasitic infection was observed in Addiremets townrnin which S. mansoni and H. worm were the most common parasites. Majority of the participantsrnhad good knowledge and positive attitude towards intestinal parasites and intestinalrnschistosomiasis.rnKey words: Intestinal parasites, Schistosomiasis, KAP, Addiremets, Western Tigray, Ethiopia.