Changes In Platelet Count And Mean Platelet Volume During Infectious And Inflammatory Diseases And Their Correlation With Esr And Crp At Zewditu Memorial Hospital Addis Ababa Ethiopia

s and inflammatory diseases have been among the major threats for publicrnhealth. Many ways of diagnosing these diseases have been developed. However, there is still a needrnfor better parameters that will help reduce the cost and increase the reliability of the diagnosis.rnEfforts have been undergoing to standardize the use of Platelet parameters with ErythrocyternSedimentation Rate (ESR) and C - reactive protein (CRP).rnObjective: To evaluate the changes in platelet count (PLT) and mean platelet volume (MPV), andrnthe relation between each of those markers with erythrocyte sedimentation rate (ESR) and C -rnreactive protein (CRP) in infectious and inflammatory diseases in Zewditu Memorial Hospital, AddisrnAbaba, Ethiopia from July 2015 – May 2016.rnMethods: A cross-sectional, hospital based study was conducted on 100 patients with infectious andrninflammatory diseases and admitted in medical ward of Zewditu Memorial Hospital. PLT, MPV,rnESR, and CRP were measured at hospitalization and discharge. Patients’ demographic and clinicalrncharacteristics were collected using formats. Whole blood was collected and measured using CellrnDyn 1800 Hematological analyzer for Platelet parameters (PLT and MPV). The serum level of CRPrnand ESR were measured using semi quantitative agglutination test and Westergren methods,rnrespectively. Values at admission and discharge were compared using paired t-test. In addition,rnPearson correlation test was used to determine the relationship between the platelet count, MPV,rnESR and CRP. Data was entered and analyzed using SPSS ver.21 statistical software and P-value lessrnthan 0.05 was considered as statistically significant.rnResult: 48 male and 52 female adult patients with infectious and inflammatory conditions wererninvolved in this study. Their mean PLT count changes from 258.5 ± 131.1(x 10 9/l)at admission torn279.5 ± 124.9 (x 109/l), P =0.001) at discharge.MPV increased during the same period but therndifference was not statistically significant (9.6 ± 1.7flvs.10.1 ± 7.9fl,P

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