Background: Intestinal helminthic infections have been suggested to play protective role from allergicrnsensitization and atopic diseases. There is a concern that deworming could increase the prevalence ofrnatopic disease in endemic populations. There is inconsistent and little information about the relationshiprnbetween helminthic infection and allergic disease in Ethiopia.rnObjective: The aim of this study was to assess the association of intestinal helminthes and atopyrn/allergic disorder in the setting of mass deworming among school children in Sululta, Oromia, Ethiopia.rnMethods: A cross sectional study was conducted among 526 school children aged 5 to 14 years fromrnthree selected government primary schools in Sululta woreda. Information on socio-demographicrncharacteristic, associated risk factors and allergic symptoms were obtained using questionnaire. Fromrnall children, fresh stool samples were collected and processed by direct wet mount, formol-etherrnconcentration and Kato-Katz technique and atopy was assessed by skin prick test (SPT). In addition,rnvenous blood was collected for eosinophil count. Data was entered and analyzed using SPSS version21rnstatistical software. The odds ratio and 95% confidence interval was calculated to assess the strength ofrnthe association. P-value less than 0.05 were considered as statistically significant.rnResults: Of the total 526 school children 58.2% (306) were females. Overall 24% (n=126/526) hadrnquestionnaire based allergic symptoms while 5.1 % (n=27/526) had skin prick test reactivity, 16.9% ofrnthem (n=89/526) had intestinal helminthic infection. All helminthic infections were with low intensityrnlevel. There was no association between helminthic infection and allergic symptoms (OR=1.30, 95%rnCI=0.778-2.171, P=0.317). Ascaris lumbricoides infection was positively associated with skin testrnreactivity (AOR=4.307, 95%CI=1.143-16.222, P=0.031). Atopy was significantly associated withrnincreased allergy symptoms (AOR=2.787, 95%CI=1.253-6.197, P=0.012). Short term deworming hadrnno effect on atopy but has a protective effect on allergic symptom.rnConclusion: Low intensity and low prevalence of helminthic infection in our findings may haverncontributed to the non-significant association of allergy and helminthes infection; however, Ascarisrnlumbricoides was positively associated with atopy. Further longitudinal study is recommended tornexamine the mechanism of Ascaris lumbricoides infection for the development of atopy.rnKeywords: Atopy, Allergy, Intestinal helminthes, School children