Prediction Of Preeclampsia During Pregnancy Using Platelet Parameters At Ayder Comprehensive Specialized And Mekelle General Hospitals In Mekelle Tigray Ethiopia

Background:Platelet abnormality is one of the most commonly identified hematologicalrnabnormality in preeclampsia.Preeclampsia is a major obstetric problem and cause of maternalrnmortality especially in developing countries. However, platelet parameter of preeclampticrnwomen is not well recognized as a tool for prediction and prognosis of preeclampsia in Ethiopia.rnObjectives: To evaluate the role of platelet parameters in prediction of preeclampsia at Ayderrncomprehensive specialized and Mekelle General Hospitals.rnMethods:A cross sectional comparative study was conducted on 219 pregnant women at ACSHrnand MGH in Mekelle city from January to March 2017.Using convenient sampling method,79rndiagnosed cases of preeclampsia and 140 healthy pregnant women were selected. Plateletrnparameters were analyzed from EDTA venous blood sample by automated hematology analyzerrn(SYSMEX-XT 4000i).One-way ANOVAsupplemented with post-hoc test was done to comparernthe mean platelet parameters difference across the three groups of women. Receiver OperatingrnCharacteristics (ROC) curve was used to calculate sensitivity, specificity, positive predictivernvalue (PPV), negative predictive value (NPV), for a given platelet parameters in discriminatingrnthe presence or the absence of preeclampsia. Pearson correlation test was used to see thernrelationship between continuous variables. The data was cleaned, entered and analyzed usingrnSPSS version 20 software. A P-value of

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