Surveillance of the prevalence of zonootic bacteria and resistant commensals in food animals is necessaryrnto control the spread of the pathogens and resistant commensal bacteria to humans through contaminatedrnanimal food products and to the environment via their faecal material. This study was designed to see thernprevalence of antibiotic resistance in enterococci from poultry and cattle; to asses the prevalence of Ecolirn0157 H7 from cattle, and that of Salmonella from cattle and poultry. Two hundred eighty cloacal swabsrncollected from poultry were examined for the presence of Salmonella and enterococci and the isolates wererntested for their resistance to an array of 8 and 11 different antibiotics, respectively. Similarly, 450 freshrnfaecal samples collected from cattle were examined for the presence of E coli 0157 H7, Salmonella andrnenterococci. The Salmonella and enterococci isolates from cattle were tested for their resistance to an arrayrnof 8 and 9 different antibiotics, respectively. Entercoccus (aecium was the most dominant species in bothrnpoultry and cattle (49.6% and 34/64), followed by Enterococcus durans (26.9% and 21/64). The prevalencernof Salmonella in poultry and cattle was 15.4% and 1.8%, respectively. None of the cattle faecal samplesrnwas positive for Escherichia coli 0157:H7. Resistance to the antibiotics tested was seen in all species fromrnpoultry. All E faecalis isolates showed susceptibility to amikacin. There was no significant difference amongrnfarms and species in their percentage of resistant isolates to the different antibiotics, except differencernamong farms in percentage mean resistant isolate for penicillin G and vancomycin (at 0=0.05). Vancomycinrnresistance was observed in 44% of enterococcal isolates from poultry in the four farms and in 17% isolatedrnfrom cattle. Multiple drug resistance (MDR) was observed in 78.2% and 90.6% enterocccal isolates fromrnpoultry and cattle, respectively. Entercoccal isolates from cattle showed resistance with varying percentagernto all antibiotics tested, except amikacin. Among the Salmonella isolates 16 from poultry and 1 from cattlernshowed MDR. The presence of MDR isolates in the commensal and pathogenic microbes is a serious publicrnheath concern. The government and concerned bodies should focus and work more in the area.rnKey words/phrase: Antibiotic resistance, Enterococci, Escherichia coli 0157:H7, MDR, Salmonella