Malaria is a serious public health and economic problem in Ethiopia for about 68% of thernpopulation. The misuse of LLINs and resistance of the vectors to most of the insecticides used inrnLLINs and IRS necessitated the need for alternative and effective control methods. Reportsrnshowed that Anopheles mosquitoes die when they feed on endectocidal drug- (like ivermectinrnand eprinomectin) treated humans and animals. This study was designed to investigate thernefficacy of LongRangeâ„¢ eprinomectin against laboratory reared Anopheles arabiensis when fedrnon treated calves. Three local breed calves treated with a therapeutic dose of LongRangeâ„¢rnEprinomectin (1ml / 50Kg body weight) and another three non-treated calves (control) werernexposed to equal numbers of An. arabiensis mosquitoes. The mosquitoes were placed in paperrncups, covered with meshed nylon cloth and then allowed to feed on calvesâ€™ neck. Subsequently,rntheir survival, fecundity, egg hatchability, larval development and adult emergence werernrecorded. Data were entered and analyzed by using the SPSS version 20. Kaplan-Meier survivalrnanalysis and, independent samples t-test were used. The survivorship of An. arabiensis that fedrnon LongRangeâ„¢ Eprinomectin treated calves up to14 days post treatment was observed to bernreduced significantly (p< 0.001). All of the mosquitoes that fed on the treated calves within 7rndays following injection were observed to die. Although not statistically significant, fecundityrnand hatchability of An. arabiensis that fed on the treated calves were reduced. Hence, treatmentrnof livestock with eprinomectin can be used to effectively control zoophagic An. arabiensis forrn7days post- injection. Therefore, the drug can be used as part of a combination vector controlrntool against An. arabiensis effectively if a repeated MDA is given to cattle in malarious regionsrnof Ethiopia.rnKey words: Anopheles arabiensis, cattle, LongRange Eprinomectin, malaria control, Ethiopia