In the face of antimalarial drug resistance, there is need to develop more effectivernantimalarial drugs that are inexpensive. In this respect, traditional medicinal plant-basedrnantimalarial products are more preferable candidates. In this study, the seeds of Dodonaearnangustifolia and the leaves of Entada abyssinica, used in indigenous medicine to treatrnmalaria in Ethiopia, were evaluated for an in vivo antimalarial activity againstrnchloroquine sensitive Plasmodium berghei ANKA strain. Acute and sub acute toxicityrnstudies of the extracts were carried out in Swiss albino mice prior to antimalarial activityrntest. Behavioral changes, mortality, weight loss, reduction in PCV, WBC and RBC count,rnin the mice were used as indicators of toxicity. All extracts revealed no obvious acute andrnsubacute toxicities on mice up to the highest (1000/750mg/kg) dose given. To assess thernantimalarial activity, male Swiss albino mice were infected by intraperitoneal inoculationrnof 106 parasitized erythrocytes. The plant extracts were solubilized in Tween 80(3%) andrnexperimental groups received once daily after 3 hours of infection for four days viarngabage. CQ- phosphate was given for positive control and vehicle for negative control.rnEach extract was none toxic and showed significant level of parasite suppressionrncompared to the negative control. The highest parasite suppressions (86.21%) atrn600mg/kg and marginal efficacy were obtained form the methanol extracts of D.rnangustifolia at 100mg/kg. The results of this study provide support for the traditionalrntherapeutic value and the reported antimalarial activity. Therefore, further investigation torndetermine the active ingredients of these plants as potential source of new antimalarialrndrugs should be carried out.rnKey words: antimalarial activity, Dodonaea anqustifolia, Entada abyssinica, in vivo,rnPlasmodium berghei.