Tuberculosis has become the major killer disease globally. As it is the case with mostrnother infectious diseases the magnitude of the problem is the highest in resource poorrncountries. There are several means to control the disease. One of these is the use ofrnvaccine (BCG). However, the vaccine offers the least protection against puhnonaryrntuberculosis, the most infectious fonn of the disease, in areas where TB is most prevalent.rnPart of the explanation for this may be that chronic infectious disease particularly,rnhehninthes, in these areas may polmize the immune response towards humoral type whenrncell mediated inununity takes the lions share in defending the body against intracellularrninfections. In order to assess whether intestinal helminthes could influence mycobacteriarnspecific immunity, we investigated the ill vivo and ill vitro mycobactelia specificrnimmune responses of helminth exposed population at Kotebe Teacher's Training College.rnOur finding was that dewonning significantly enhanced the ill vitro lymphocyternproliferative responses, IFN-y and IL-IO production in response to mycobacterialrnantigens and a T cell mitogen, PHA, compared to untreated controls. Moreover, therninitially PPD non reactive subjects were BCG vaccinated and later tested forrnmycobacteria specific immune responses ill vivo and ill vitro. We found that BCG, whenrngiven after deworming caused significant improvement in T cell proliferation and IFN-yrnproduction compared to pre-vaccination levels in response to a mycobacterial antigen,rnPPD, whereas in the placebo group the difference was not significant. This findingrnsupport the notion that intestinal hehninthes may impair immune responses againstrnmycobactelial infections and that BCG vaccination may confer better protection if givenrnafter dewonning in helminth exposed population which is an already established notionrnin veterinary medicine.