Characterization Of Peripheral Blood Leucocyte Subsets In Acute Plasmodium Falciparum And P. Vivax Malaria Infections At Wonji Sugar Estate Ethiopia

The aim of this study was to assess the absolute counts and percentages of lymphocyternand granulocyte subsets and monocytes in acute P. falciparum (pf) and P. vivax (pv)rninfections. Effect of HIV infection on haematological and Parasitological values wasrnalso assessed. Three-colour flow cytometry was used for enumerating the immunerncells. Coulter Counter was used to determine haematological values. Parasite speciesrnwere detected using light microscopy. HIV testing was done using Determine, ELISArnand Western blot. Data was analysed using STATA and SPSS softwares. 166 acuternmalaria patients of whom 82 (49.4%) were infected with pf, 81 (48.8%) infected withrnpv, and 3 (1.8%) infected with both pf and pv were included in the study. 8 (4.8%) (3rnpf and 5 pv patients) were HIV positives. As a control, 87 age-matched subjects (46rnHIV negatives and 41 HIV positives) were included. Trophozoite density wasrnincreased in HIV positive falciparum patients than in the negatives (P=0.031).rnMoreover, although statistically insignificant, sexual and asexual parasitemia wasrnhigher in HIV positive pv patients than in the negatives. Haemoglobin (hgb),rnhaematocrit (hct) and platelet (plt) levels were lower in pf and pv malaria patientsrn(P

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